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Diabetic retinopathy is an important cause of blindness, and occurs as a result of long term accumulated damage to the small blood vessels in the retina.
Among the 47 studies, 16 provided information on incidence by age group.
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Between 90 and 95 percent of all diabetes cases are type 2, and the disease typically develops in people who are older than 45.
The significant determinants are polymorphisms of class II HLA genes encoding DQ and DR4 DQ8, with DR3 DQ2, found in 90 of T1DM patients.
However, it can also be the first presentation of type 1 diabetes.
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