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Antioxidative and Anti-Inflammatory Properties of Cannabidiol Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative 11 Best CBD Oils for Inflammation

Antioxidative and Anti-Inflammatory Properties of Cannabidiol

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Abstract

Cannabidiol (CBD) is one of the main pharmacologically active phytocannabinoids of Cannabis sativa L. CBD is non-psychoactive but exerts a number of beneficial pharmacological effects, including anti-inflammatory and antioxidant properties. The chemistry and pharmacology of CBD, as well as various molecular targets, including cannabinoid receptors and other components of the endocannabinoid system with which it interacts, have been extensively studied. In addition, preclinical and clinical studies have contributed to our understanding of the therapeutic potential of CBD for many diseases, including diseases associated with oxidative stress. Here, we review the main biological effects of CBD, and its synthetic derivatives, focusing on the cellular, antioxidant, and anti-inflammatory properties of CBD.

Keywords: cannabidiol, cannabidiol synthetic derivatives, endocannabinoids, oxidative stress, lipid peroxidation, inflammation, membrane receptors

1. Introduction

The endocannabinoid system is an important molecular system responsible for controlling homeostasis and is becoming an increasingly popular target of pharmacotherapy. Endocannabinoids are ester, ether, and amide derivatives of long chain polyunsaturated fatty acids (PUFAs), such as arachidonic acid, and they act mainly as cannabinoid receptor ligands [1]. Endocannabinoids belong to a large group of compounds with a similar structure and biological activity called cannabinoids. Cannabinoids are chemical derivatives of dibenzopyrene or monoterpenoid, and to date over four hundred have been identified. The most important of these are Δ 9 -tetrahydrocannabinol (Δ 9 -THC), Δ 8 -tetrahydrocannabinol (Δ 8 -THC), cannabinol (CBN), and cannabidiol (CBD), and they are members of a large group of biologically active compounds found in Cannabis sativa L. [2]. The medical use of cannabinoids, in particular phytocannabinoids, has been one of the most interesting approaches to pharmacotherapy in recent years.

CBD is one of the main pharmacologically active phytocannabinoids [3]. It is non-psychoactive, but has many beneficial pharmacological effects, including anti-inflammatory and antioxidant effects. [4]. In addition, it belongs to a group of compounds with anxiolytic, antidepressant, antipsychotic, and anticonvulsant properties, among others [5]. The biological effects of cannabidiol, including the various molecular targets, such as cannabinoid receptors and other components of the endocannabinoid system, with which it interacts, have been extensively studied. The therapeutic potential of CBD has been evaluated in cardiovascular, neurodegenerative, cancer, and metabolic diseases, which are usually accompanied by oxidative stress and inflammation [6]. One of the best studied uses of CBD is for therapeutic effect in diabetes and its complications in animal and human studies [7]. CBD, by activating the cannabinoid receptor, CB2, has been shown to induce vasodilatation in type 2 diabetic rats [8,9], and by activating 5-HT1A receptors, CBD showed a therapeutic effect in diabetic neuropathy [10]. Moreover, this phytocannabinoid accelerated wound healing in a diabetic rat model by protecting the endothelial growth factor (VEGF) [11]. In addition, by preventing the formation of oxidative stress in the retina neurons of diabetic animals, CBD counteracted tyrosine nitration, which can lead to glutamate accumulation and neuronal cell death [12].

This review summarizes the chemical and biological effects of CBD and its natural and synthetic derivatives. Particular attention was paid to the antioxidant and anti-inflammatory effects of CBD and its derivatives, bearing in mind the possibilities of using this phytocannabinoid to protect against oxidative stress and the consequences associated with oxidative modifications of proteins and lipids. Although CBD demonstrates safety and a good side effect profile in many clinical trials [4], all of the therapeutic options for CBD discussed in this review are limited in a concentration-dependent manner.

2. Molecular Structure of CBD

CBD is a terpenophenol compound containing twenty-one carbon atoms, with the formula C21H30O2 and a molecular weight of 314.464 g/mol ( Figure 1 ). The chemical structure of cannabidiol, 2-[1R-3-methyl-6R-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol, was determined in 1963 [13]. The current IUPAC preferred terminology is 2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol. Naturally occurring CBD has a (−)-CBD structure [14]. The CBD molecule contains a cyclohexene ring (A), a phenolic ring (B) and a pentyl side chain. In addition, the terpenic ring (A) and the aromatic ring (B) are located in planes that are almost perpendicular to each other [15]. There are four known CBD side chain homologs, which are methyl, n-propyl, n-butyl, and n-pentyl [16]. All known CBD forms ( Table 1 ) have absolute trans configuration in positions 1R and 6R [16].

Chemical structure of cannabidiol (CBD) [16].

Table 1

Compound R 1 R 2 R 3
cannabidiolic acid (CBDA-C5) COOH n-C5H11 H
(–)-cannabidiol (CBD-C5) H n-C5H11 H
cannabidiol monomethyl ether (CBDM-C5) H n-C5H11 Me
Cannabidiol-C4 (CBD-C4) H n-C4H9 H
cannabidivarinic acid (CBDVA-C3) COOH n-C3H7 H
(–)-cannabidivarin (CBDV-C3) H n-C3H7 H
cannabidiorcol (CBD-C1) H CH3 H

The CBD chemical activity is mainly due to the location and surroundings of the hydroxyl groups in the phenolic ring at the C-1′ and C-5′ positions (B), as well as the methyl group at the C-1 position of the cyclohexene ring (A) and the pentyl chain at the C-3′ of the phenolic ring (B). However, the open CBD ring in the C-4 position is inactive. Due to the hydroxyl groups (C-1′ and C-5′ in the B ring), CBD can also bind to amino acids such as threonine, tyrosine, glutamic acid, or glutamine by means of a hydrogen bond [17].

CBD has potential antioxidant properties because its free cationic radicals exhibit several resonance structures in which unpaired electrons are distributed mainly on ether and alkyl moieties, as well as on the benzene ring [18].

3. Biological Activity of CBD

CBD has a wide spectrum of biological activity, including antioxidant and anti-inflammatory activity, which is why its activity in the prevention and treatment of diseases whose development is associated with redox imbalance and inflammation has been tested [4,19,20]. Based on the current research results, the possibility of using CBD for the treatment of diabetes, diabetes-related cardiomyopathy, cardiovascular diseases (including stroke, arrhythmia, atherosclerosis, and hypertension), cancer, arthritis, anxiety, psychosis, epilepsy, neurodegenerative disease (i.e., Alzheimer’s) and skin disease is being considered [20,21,22]. Analysis of CBD antioxidant activity showed that it can regulate the state of redox directly by affecting the components of the redox system and indirectly by interacting with other molecular targets associated with redox system components.

3.1. Direct Antioxidant Effects of CBD

CBD has been shown to affect redox balance by modifying the level and activity of both oxidants and antioxidants ( Figure 2 and Figure 3 ). CBD, like other antioxidants, interrupts free radical chain reactions, capturing free radicals or transforming them into less active forms. The free radicals produced in these reactions are characterized by many resonance structures in which unpaired electrons are mainly found on the phenolic structure, suggesting that the hydroxyl groups of the phenol ring are mainly responsible for CBD antioxidant activity [18].

Direct antioxidant effects of CBD (closed arrows indicate reducing effects; opened arrows indicate inducing action).

Indirect antioxidant and anti-inflammatory effects of CBD (closed arrows indicate inhibition; opened arrows indicate activation.

CBD reduces oxidative conditions by preventing the formation of superoxide radicals, which are mainly generated by xanthine oxidase (XO) and NADPH oxidase (NOX1 and NOX4). This activity was shown in the renal nephropathy model using cisplatin-treated mice (C57BL/6J) [23] and in human coronary endothelial cells (HCAEC) [24]. In addition, CBD promoted a reduction in NO levels in the liver of doxorubicin-treated mice [25] and in the paw tissue of Wistar rats in a chronic inflammation model [26].

CBD also reduces reactive oxygen species (ROS) production by chelating transition metal ions involved in the Fenton reaction to form extremely reactive hydroxyl radicals [27]. It was shown that CBD, acting similarly to the classic antioxidant butylated hydroxytoluene (BHT), prevents dihydrorodamine oxidation in the Fenton reaction [28]. In addition, CBD has been found to decrease β-amyloid formation in neurons by reducing the concentration of transition metal ions [29].

In addition to the direct reduction of oxidant levels, CBD also modifies the redox balance by changing the level and activity of antioxidants [19,26]. CBD antioxidant activity begins at the level of protein transcription by activating the redox-sensitive transcription factor referred to as the nuclear erythroid 2-related factor (Nrf2) [30], which is responsible for the transcription of cytoprotective genes, including antioxidant genes [31]. CBD was found to increase the mRNA level of superoxide dismutase (SOD) and the enzymatic activity of Cu, Zn- and Mn-SOD, which are responsible for the metabolism of superoxide radicals in the mouse model of diabetic cardiomyopathy type I and in human cardiomyocytes treated with 3-nitropropionic acid or streptozotocin [32]. Repeated doses of CBD in inflammatory conditions were found to increase the activity of glutathione peroxidase and reductase, resulting in a decrease in malonaldehyde (MDA) levels, which were six times higher in untreated controls [26]. Glutathione peroxidase activity (GSHPx) and glutathione level (GSH) were similarly changed after using CBD to treat UVB irradiated human keratinocytes. The high affinity of CBD for the cysteine and selenocysteine residues of these proteins is a possible explanation for this observation [33]. It is known that under oxidative conditions, alterations in enzymatic activity may be caused by oxidative modifications of proteins, mainly aromatic and sulfur amino acids [34]. It has also been suggested that the reactive CBD metabolite cannabidiol hydroxyquinone reacts covalently with cysteine, forming adducts with, for example, glutathione and cytochrome P450 3A11, and thereby inhibiting their biological activity [35]. In addition, CBD has been found to inhibit tryptophan degradation by reducing indoleamine-2,3-dioxygenase activity [36]. CBD also supports the action of antioxidant enzymes by preventing a reduction in the levels of microelements (e.g., Zn or Sn), which are usually lowered in pathological conditions. These elements are necessary for the biological activity of some proteins, especially enzymes such as superoxide dismutase or glutathione peroxidase [25].

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By lowering ROS levels, CBD also protects non-enzymatic antioxidants, preventing their oxidation, as in the case of GSH in the myocardial tissue of C57BL/6J mice with diabetic cardiomyopathy [32] and doxorubicin-treated rats [25]. An increase in GSH levels after CBD treatment was also observed in mouse microglia cells [37] and in the liver of cadmium poisoned mice [25]. This is of great practical importance because GSH cooperates with other low molecular weight compounds in antioxidant action, mainly with vitamins such as A, E, and C [38]. CBD exhibits much more antioxidant activity (30–50%) than α-tocopherol or vitamin C [4].

3.2. The Consequences of Direct Antioxidant Action of CBD

The result of an imbalance between oxidants and antioxidants is oxidative stress, the consequences of which are oxidative modifications of lipids, nucleic acids, and proteins. This results in changes in the structure of the above molecules and, as a result, disrupts their molecular interactions and signal transduction pathways [39]. Oxidative modifications play an important role in the functioning of redox-sensitive transcription factors (including Nrf2 and the nuclear factor kappa B (NFκB). As a consequence, oxidative modifications play a role in the regulation of pathological conditions characterized by redox imbalances and inflammation, such as cancer, inflammatory diseases, and neurodegenerative diseases [40,41].

In this situation, one of the most important processes is lipid peroxidation, which results in the oxidation of polyunsaturated fatty acids (PUFA), such as arachidonic, linoleic, linolenic, eicosapentaenoic, and docosahexaenoic acids [42]. As a result of the ROS reaction with PUFAs, lipid hydroperoxides are formed, and as a result of oxidative fragmentation, unsaturated aldehydes are generated, including 4-hydroxynenenal (4-HNE), malonodialdehyde (MDA) or acrolein [43]. In addition, the propagation of oxidation chain reactions, especially with regard to docosahexaenoic acid, can lead to oxidative cyclization, resulting in production of isoprostanes or neuroprostanes [44]. The formation of lipid peroxidation products directly affects the physical properties and functioning of the cell membranes in which they are formed [42]. Due to their structure (the presence of a carbonyl groups and carbon-carbon double bonds) and electrophilic character, generated unsaturated aldehydes are chemically reactive molecules that can easily form adducts with the majority of the cell’s nucleophilic components, including DNA, lipids, proteins, and GSH [45]. For example, 4-hydroxynonenal (4-HNE) has been identified as a stimulator of the cytoprotective transcription factor Nrf2, an inhibitor of antioxidant enzymes (e.g., catalase and thioredoxin reductase) and a pro-inflammatory factor acting through the NFκB pathway [46]. These reactions reduce the level of reactive lipid peroxidation products, while increasing the formation of adducts with proteins that promote cell signaling disorders, thus stimulating metabolic modifications that can lead to cellular dysfunction and apoptosis [47,48].

In addition to lipid peroxidation, oxidative conditions also favor the oxidative modification of proteins by ROS. The aromatic and sulfhydryl amino acid residues are particularly susceptible to modifications, and can result in production of levodopa ( l -DOPA) from tyrosine, ortho-tyrosine from phenylalanine, sulfoxides and disulfides from cysteine, and kynurenine from tryptophan, among others [49]. The resulting changes in the protein structures cause disruption of their biological properties and, as in the case of lipid modification, affect cell metabolism, including signal transduction [46,50].

One of the most noticeable CBD antioxidant effects is the reduction in lipid and protein modifications [25,51]. CBD supplementation has been found to reduce lipid peroxidation, as measured by MDA levels, in mouse hippocampal (HT22) neuronal cells depleted of oxygen and glucose under reperfusion conditions [51]. A reduction in lipid peroxidation following CBD supplementation has also been shown in C57BL/6J mouse liver homogenates, assessed by 4-HNE levels [52]. CBD also protected the brain against oxidative protein damage caused by D-amphetamine in a rat model of mania [53]. On the other hand, CBD induced ubiquitination of the amyloid precursor protein (APP), an indicator of cellular changes in the brain of people with Alzheimer’s disease, when evaluated in human neuroblastoma cells (SHSY5Y APP+ ) [54]. In addition, CBD treatment has recently been shown to exhibit an unusual protective effect by transporting proteins including multidrug-1 resistance protein and cytosol transferases, such as S-glutathione-M1 transferase, prior to modification by lipid peroxidation products. This prevents elevation of 4-HNE and MDA adduct levels in fibroblast cell culture [55]. It was also shown that this phytocannabinoid reduced the level of small molecular αβ-unsaturated aldehydes in the myocardial tissue of Sprague-Dawley rats and mice with diabetic cardiomyopathy, and in the liver of mice from the acute alcohol intoxication model [21,25,32]. Additionally, CBD caused a reduction in the level of PUFA cyclization products, such as isoprostanes, in the cortex of transgenic mice (APPswe/PS1ΔE9) with Alzheimer’s disease [56]. Thus, CBD protects lipids and proteins against oxidative damage by modulating the level of oxidative stress, which participates in cell signaling pathways.

3.3. Indirect Antioxidant Effects of CBD

Various cell metabolic systems, including the endocannabinoid system, are involved in the regulation of redox balance. Thus, the action of CBD as a phytocannabinoid may support the biological activity of the endocannabinoid system. CBD has recently been shown to modulate the endocannabinoid system activity by increasing anandamide (AEA) levels [5], which can affect cannabinoids signaling, including their interaction on cannabinoid receptors [57]. However, it is known that the peroxisome proliferator-activated receptor alpha (PPAR-α), for example, activated by endocannabinoids, directly regulates the expression of antioxidant enzymes such as superoxide dismutase by interacting with their promoter regions [58]. Therefore, it is believed that the most important antioxidant activity of CBD, like endocannabinoids, is associated with its effect on receptors. CBD, depending on the concentration, can activate, antagonize or inhibit cannabinoid receptors (CB1 and CB2), as well as ionotropic (TRP) and nuclear (PPAR) receptors ( Figure 4 ) [52,59,60].

11 Best CBD Oils for Inflammation

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CBD oil is a natural product that has been used for centuries to treat many different conditions. It’s not just your average “ancient medicine.” The use of CBD oil spans across generations and cultures, all the way back to ancient China and India.

Today we use the best CBD oils for inflammation, fibromyalgia, and other conditions for a variety of people who prefer a more natural approach to pain relief and ailments.

What is CBD oil?

Cannabidiol, or CBD for short, is a natural compound found in the cannabis plant. It contains untraceable amounts of tetrahydrocannabinol (THC), the principal psychoactive element in marijuana that gives users that “high” sensation.

The use of cannabis as medicine dates back to ancient times and now, researchers are finding that CBD has a variety of therapeutic effects. With the help of CBD oil, you can easily find relief from inflammation, pain, anxiety, stress, seizures, and an array of other conditions without having to worry about experiencing the “high” sensation.

CBD should not be confused with THC or other marijuana products that contain high levels of THC and will produce a high sensation. CBD oil contains only trace amounts of THC and has proven to have an array of benefits for medical use.

Is CBD good for inflammation?

Yes, CBD oil for inflammation is pure bliss.

CBD has been shown to provide relief from a number of different inflammatory conditions. It’s an effective method of giving your immune and nervous system a break and helping with pain and the effects of swelling.

By reducing the activity in overactive immune responses or neural responses, CBD is able to provide relief to the affected area and the rest of the body.

Which CBD oil is good for inflammation?

CBD oil for inflammation comes in various forms, including tinctures, edibles, capsules, and topical oils.

The best CBD oil for inflammatory pain is one that contains full-spectrum or broad-spectrum extracts of cannabinoids. These extracts supply the body with a number of different compounds, including CBD, THC, and other phytocannabinoids.

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When choosing a CBD oil for inflammation, look for a product that’s labeled as full-spectrum or broad-spectrum and make sure it contains cannabidiol (CBD). CBD is the compound in cannabis known for its positive health effects, and you can find it at high levels in hemp.

11 Best CBD Oils for Inflammation

What is inflammation?

Inflammation is a common condition that causes pain and discomfort in muscles, joints, and other parts of the body. When you have inflammation, your immune system triggers an inflammatory response in order to defend your body from invading microorganisms or harmful stimuli.

A small amount of inflammation helps the body heal after an injury or illness but when it becomes chronic, inflammation can cause many problems including joint pain, autoimmune disease, high blood pressure, cardiovascular disease, Alzheimer’s disease, cancer cells, and other serious health conditions.

What makes CBD oil so effective for inflammation?

CBD oil is effective for treating inflammation because of the way it interacts with cells in your immune system. When you have chronic inflammation, your immune system continuously sends signals to your brain that there is a problem and these signals trigger a stress response.

When you use CBD oil for chronic inflammatory conditions, the cannabinoids interact with the endocannabinoid system in your body. This system is responsible for keeping the immune system calm after it has detected a threat in the body.

When you use CBD oil, these cannabinoid receptors send signals to your immune cells to stop producing inflammatory proteins and prevent them from multiplying, therefore stopping the inflammatory response quickly.

What are the benefits of using CBD oil for inflammation?

CBD oil is the most effective natural relief for inflammation because it is non-psychoactive, meaning you will not feel high or groggy after using CBD oil.

Here are some of the most common benefits associated with CBD oil:

· CBD oil is a safe alternative treatment to over the counter drugs

· Can relieve pain, swelling, and stiffness

· Can treat chronic pain

· May reduce acne symptoms

· May help with mental health disorders like depression, anxiety, eating disorders, and post-traumatic stress disorder (PTSD)

· May improve skin conditions like rashes, dryness, itchiness, and swelling

· CBD oil contains 0% THC. This means that while CBD oil has many of the same benefits as medical cannabis, you will not feel high or groggy after using CBD oil.

What Are The Best CBD Oils For Inflammation?

There are many different types of CBD oils available for purchase online and in local health stores throughout the country.

CBD oils can be extracted from different types of cannabis plants and the desired compound can be isolated based on its level of saturation. Cannabis cultivators are able to manipulate the sativa or indica compounds in marijuana plants by controlling how much THC is naturally present in the plant.

This allows CBD oil manufacturers to produce oils that contain varying levels of CBD, resulting in different strengths that provide unique benefits.

CBD oils are classified as either full spectrum or broad-spectrum based on their interaction with other compounds in marijuana plants. Full spectrum CBD oil does not contain synthetic additives and has a more natural flavor than broad-spectrum CBD oil which is processed to remove some of the plant material that can alter the flavor.

There are no additives, preservatives, or sweeteners in most of those CBD oils for inflammation we included in our list. People suffering from chronic pain, stress, arthritis, anxiety, and depression can benefit greatly from taking CBD oil daily. Kind of like an herbal supplement to daily vitamins, CBD provides additional benefits like stress relief and mental clarity.

Here Are The 11 Best CBD Oils For Inflammation:

We’ve already shared what we feel the best CBD oils for inflammation are, but we wanted to dive deeper into each brand so you can get to know the best options for you.

1. Penguin CBD

Image courtesy Penguin CBD

Looking for a CBD option that’s fun and fresh? Penguin CBD has you covered! They offer mint, citrus, strawberry, cookies & cream, and natural flavors in four strengths (250 mg, 600 mg, 1,000 mg, and 2,500 mg). Plus, their broad-spectrum oil is always made to order so it arrives fresh to your door.

2. Everest

Image courtesy Everest

Looking for a trustworthy CBD extract? Look no further than Everest! Their hemp is grown using only the best farming practices, and they take transparency and quality seriously. Everest products are lab-tested to ensure that you’re getting the highest quality possible. With Everest, you can trust that you’re getting the purest CBD available!

3. R+R Medicinals

R+R Medicinals is quickly becoming one of the most trusted and popular CBD brands by proving one thing – they make the CBD that works. Using supercritical CO2 extraction on their proprietary Cherry strain of USDA Certified Organic hemp, they yield an unparalleled profile of cannabinoids, terpenes, and other phytonutrients in their products that translate into guaranteed performance. Their 1000mg Fresh Mint Tincture is their best seller and of incredible value for a Full-Spectrum product at $46.99.

4. BATCH CBD

Naturally formulated to ease life’s stressors, BATCH has a blend that works for everyone. Their formula philosophy is simple: maximize effectiveness and minimize fluffy ingredients. To help with inflammation, we recommend their staples: Original CBD Oil Tincture or Calm CBD Oil Tincture . They both have cultivated rave reviews, so it’s hard not to love them! Choose strengths from 500mg to 3000mg depending on your blend choice.

5. CBDfx

Image courtesy CBDfx

These full-spectrum hemp extract CBD oil tinctures are perfect for those looking for a powerful punch. Available in two delicious flavors, citrus, and mint chocolate, these tinctures are packed with beneficial cannabinoids, including THC, CBN, and CBC. At 18+, these products are potent. Indulge in the refreshing sweetness of mint chocolate or the light citrus flavor today.

6. Verma Farms

Image courtesy Verma Farms

Looking for a balanced lifestyle? Verma Farms CBD oil kits can help! Their Natural CBD oil is perfect for waking up your senses, their Lemon Lime CBD oil helps you focus, and their Mint CBD oil relaxes you at night. With Forbes and Entrepreneur Media ranking Verma Farms #1, you know you can trust them to provide the best quality CBD oils for inflammation.

7. Sunday Scaries

Image courtesy Sunday Scaries

Sunday Scaries are the perfect CBD oil for those moments when you need to relax and chill out before bed. This unique blend of vitamins D3 and B12 helps keep your mind from racing, promoting a more restful pain-free sleep. Sunday Scaries is also designed for those times when you’re traveling and need a stronger dose of CBD.

8. CBDistillery

Image courtesy CBDistillery

CBDistillery has a wide variety of CBD oil tinctures to choose from. If you’re looking for relief and relaxation, their full-spectrum CBD oil tinctures are perfect for you. Or if you want to get some shut-eye, their sleep CBD oil tinctures with CBN will do the trick.

9. Charlotte’s Web

Image courtesy Charlotte’s Web

Charlotte’s Web is the perfect choice for rookies and seasoned users alike. If you’re new to CBD, we recommend starting with their 17 mg/ml tincture. If you’re looking for a more potent product, Charlotte’s Web offer options with higher CBD levels. Their THC-free broad-spectrum CBD oil is perfect if you’re only interested in CBD oil without THC.

10. LEVEL SELECT

LEVEL SELECT CBD is a popular relief brand that is changing both the CBD and pain relief categories. Their CBD Oil Drops were developed with doctors and are trusted by professional athletes to provide Next Level Relief, Recovery, and Rest. Their products are formulated with premium, high-performance CBD to deliver results you can feel. LEVEL SELECT CBD produces their own CBD, and because of that, can deliver the best products for the best prices.

LEVEL SELECT CBD Oil Drops come in four different varieties to help meet your relief needs, so you can achieve your goals.

Level 1 CBD Oil Drops are formulated to relax muscles and treat everyday discomfort, with 20mg of CBD per serving. Available in Mint flavor in 1oz and 2oz sizes.

Level 2 CBD Oil Drops are higher strength for higher levels of muscle soreness, with 40mg of CBD per serving. Available in Mint and Unflavored in 1oz and 2oz sizes.

Level 3 CBD Oil Drops are the maximum strength formulation for when you need the most relief, with over 80mg of CBD per serving. Available in Mint flavor in 1oz and 2oz sizes.

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Level ZZZ CBD Oil Drops combine high-potency CBD with melatonin to help you get Next Level Rest, with 40mg of CBD per serving. Available in Natural Vanilla flavor in 1oz and 2oz sizes.

Save 25% today when you use code DISC25 at checkout.

11. Green Roads

Image courtesy Green Roads

Looking for relief from inflammation? Green Roads has you covered with a wide range of CBD oil alternatives, including full-spectrum CBD oil and broad-spectrum CBD. With different formulas and concentrations to choose from, finding the perfect fit is easy.

What does CBD oil feel like?

CBD oil has a number of different effects on the body. It tends to relax muscles throughout the body, which can help with aches and pains.

This bliss-inducing feeling is what makes CBD oil for pain so popular. It can be taken in various forms, including tinctures, capsules, edibles, or topical oils.

CBD Oil Tinctures

You can take CBD oil tinctures sublingually (under the tongue), orally (swallow), or add them to your food and beverages.

CBD Capsules

CBD capsules are a convenient way to get your daily intake of cannabidiol. They come in all types of flavors so you can easily find some that suit your taste buds!

CBD Edibles

If you love cooking with cannabis, CBD edibles are the product for you! These easy-to-make treats are popping up

CBD Topicals

CBD topicals are applied directly to the affected area. They work through a variety of means, including increasing cannabinoid receptor activity and through anti-inflammatory properties.

What does CBD oil taste like?

CBD oils vary in flavor, which you can choose depending on your preference. There are sweet flavors like peppermint and vanilla, but there are also more earthy flavors like hemp seed and coffee.

What is the strongest CBD oil you can buy over the counter?

The strongest CBD oils that you can buy over the counter are full-spectrum extracts.

You should be looking for a tincture or oil that is full-spectrum and organic, meaning it contains all parts of the hemp plant including CBD, CBC, CBG, CBN, terpenes (oils that give the cannabis its aroma), and flavonoids.

What is the best CBD oil for pain relief?

A variety of factors can contribute to your experience with CBD oil for pain, including concentration levels, metabolism, age, activity level, the source of the hemp plant used in extracting it (sativa or indica), and more. But remember that there’s no one CBD oil that’s right for everyone.

CBD concentrations will be different in every individual due to factors like metabolism, weight, activity level, etc. Be sure to experiment with the concentration levels until you find what works for you.

What are the benefits of CBD oil for inflammation?

CBD oil is an effective treatment for swelling, chronic pain, sleep disorders, and anxiety – just to name a few! Check out these health conditions that CBD oil can help treat:

· Migraines and other headaches

· Nausea from chemotherapy or other ailments

· General chronic pain issues, including neuropathic pain.

· Anxiety and depression

CBD oil has the ability to provide relief for these conditions because of its neuroprotective properties. It helps support healthy brain cell development by enhancing communication between brain cells – which means you’ll see fewer disorders like anxiety and depression.

Why choose CBD over other treatments?

Lots of different pharmaceutical drugs are used to treat pain and inflammation. However, these products can be expensive and come with a whole host of nasty side effects.

CBD oil is a natural remedy for inflammatory pain and swelling. It has few or no side effects and is effective at treating chronic pain conditions.

Are there side effects of CBD oil for inflammation?

CBD oil is relatively safe, but like any medicine, it could cause an allergic reaction.

However, the chances of this happening are slim to none because CBD has no psychoactive effects (unlike THC, which does).

An allergic reaction would look like hives or other signs of inflammation over the whole body, whereas a reaction to THC would cause symptoms in just one area (most likely your head and neck).

Where can you buy CBD oil for inflammation?

There are plenty of places where you can get CBD oil. Depending on where you live, it might be easier to find online than in local dispensaries.

You can buy CBD oil at:

· Your local health and wellness store

· An online store with an extensive product list, like eBay or Amazon.

· Independent dispensaries in your area (if CBD is legal where you live)

How to choose the best CBD oil for inflammation?

There are many factors that affect how CBD oil will impact your symptoms. How much CBD is in the product, the quality of the extract, and even where you buy it can make a difference.

Choosing to purchase oil with little CBD may be frustrating because you’ll have to take more servings than someone who chooses a higher dose. If you want a product that works quickly, then you should buy one that has a lot of CBD.

However, high doses can cause drowsiness or dizziness. In this case, you could purchase a lower dose and take it at night to help with sleep problems. There are even certain brands that offer different types of extracts for daytime and nighttime relief.

Be sure to reach each company’s profile and details on every CBD oil option so that you know you’re buying the best CBD oil for inflammation relief.

Just to recap … we highly recommend these brands of CBD oils for inflammation

11 Best CBD Oils for Inflammation

7. Sunday Scaries

9. Charlotte’s Web

How fast does CBD work for inflammation?

CBD oil works quickly to help with inflammation because it’s a natural remedy.

It’ll take just a few minutes after your first serving for your body to feel the effects of CBD. It acts fast, so you don’t have to wait long before you can go about your day without worrying about painful swelling.

Is there anything else I need to know about CBD oil for inflammation?

If you’re wondering how much CBD oil you should take, follow the instructions on your product packaging. Some people may need to start with a small serving and work their way up – especially if they’re taking a high dose.

Others can take several servings at once without feeling overwhelmed by too much of the product.

In addition to taking CBD, there are other things you can do to reduce inflammation naturally. Some of these include:

· Meditating regularly for stress-relief

· Exercising to reduce stress

· Eating a nutrient-dense diet that’s full of vegetables and healthy fats

· Drinking plenty of water throughout the day.

Take control of your life again by using CBD oil for inflammation. It’ll bring you relief from chronic pain and help you live a happier, healthier life.

How can you tell quality CBD oil?

When you’re purchasing CBD oil, it’s important to know what makes quality CBD oil. Different industries have different standards of quality control and CBD companies each have their own ideas about how to determine the best product for their customers.

The internet can be a great resource for information about brands that are selling high-quality products with proven standards of extraction. You can also find blogs that offer advice on CBD products, offering details about the products they’ve tried and their experiences with them.

This is a great way to find out more information about what brands are selling CBD oil that actually works well for your needs.

If you aren’t buying from a reputable brand, then you might have to do more research to find out if the product is safe. You can also chat with other CBD users or ask your doctor about their experiences with different brands of CBD oil for inflammation to help determine which one is right for you.

CBD oil is a natural remedy that offers a variety of benefits. However, you need to be careful about where you purchase it from and what’s in the product.

Evaluate your options carefully to find a brand with a great reputation so that you can enjoy CBD oil for inflammation without any side effects.

Now that you know all about CBD oil for inflammation, you can start feeling better right away. Be sure to try out a few different brands and doses to find the best one for your needs.

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