Crude marijuana extract competed with estradiol for binding to the estrogen receptor of rat uterine cytosol. Condensed marijuana smoke also competed with estradiol for its receptor. Pure delta 9-tetrahydrocannabinol, however, did not interact with the estrogen receptor. Ten delta 9-tetrahydrocannabi … Some studies have shown that CBD oil and estrogen may be related as CBD acts as an aromatase inhibitor. Read more.
Marijuana: interaction with the estrogen receptor
Crude marijuana extract competed with estradiol for binding to the estrogen receptor of rat uterine cytosol. Condensed marijuana smoke also competed with estradiol for its receptor. Pure delta 9-tetrahydrocannabinol, however, did not interact with the estrogen receptor. Ten delta 9-tetrahydrocannabinol metabolites also failed to compete with estradiol for its receptor. Of several other common cannabinoids tested, only cannabidiol showed any estrogen receptor binding. This was evident only at very high concentrations of cannabidiol. Apigenin, the aglycone of a flavinoid phytoestrogen found in cannabis, displayed high affinity for the estrogen receptor. To assess the biological significance of these receptor data, estrogen activity was measured in vivo with the uterine growth bioassay, using immature rats. Cannabis extract in large doses exhibited neither estrogenic nor antiestrogenic effects. Thus, although estrogen receptor binding activity was observed in crude marijuana extract, marijuana smoke condensate and several known components of cannabis, direct estrogenic activity of cannabis extract could not be demonstrated in vivo.
Nieto A, García C, López de Haro MS. Nieto A, et al. Biochem Int. 1990;21(2):305-11. Biochem Int. 1990. PMID: 2403370
Reiner GC, Katzenellenbogen BS, Bindal RD, Katzenellenbogen JA. Reiner GC, et al. Cancer Res. 1984 Jun;44(6):2302-8. Cancer Res. 1984. PMID: 6547074
Morozova TM, Merkulova TI, Martynov V, Iaguzhinskaia VP, Shkodinskaia EN. Morozova TM, et al. Eksp Onkol. 1984;6(2):50-4. Eksp Onkol. 1984. PMID: 6510335 Russian.
McPartland JM, Pruitt PL. McPartland JM, et al. Altern Ther Health Med. 1999 Jul;5(4):57-62. Altern Ther Health Med. 1999. PMID: 10394675 Review.
Agurell S, Halldin M, Lindgren JE, Ohlsson A, Widman M, Gillespie H, Hollister L. Agurell S, et al. Pharmacol Rev. 1986 Mar;38(1):21-43. Pharmacol Rev. 1986. PMID: 3012605 Review. No abstract available.
DeLarge AF, Winsauer PJ. DeLarge AF, et al. Horm Behav. 2021 Jan;127:104883. doi: 10.1016/j.yhbeh.2020.104883. Epub 2020 Nov 23. Horm Behav. 2021. PMID: 33160960 Free PMC article.
Sansone A, Romanelli F, Sansone M, Lenzi A, Di Luigi L. Sansone A, et al. Endocrine. 2017 Jan;55(1):37-44. doi: 10.1007/s12020-016-0975-9. Epub 2016 May 4. Endocrine. 2017. PMID: 27145756 Review.
Yang X, Hegde VL, Rao R, Zhang J, Nagarkatti PS, Nagarkatti M. Yang X, et al. J Biol Chem. 2014 Jul 4;289(27):18707-18. doi: 10.1074/jbc.M113.545210. Epub 2014 May 19. J Biol Chem. 2014. PMID: 24841204 Free PMC article.
Does CBD oil increase estrogen levels?
I am a female with a hormonal imbalance that leads to a very irregular and sometimes absent menstrual cycle and sometimes (not always) severe periods with painful menstrual cramps. Apparently, I have low estrogen levels, which is one of the causes of these symptoms. Does CBD oil affect hormones and can it help with a hormonal imbalance? Also, does CBD oil affect hormones differently if you are a male or female?
anonymous ( Tuesday, September 28, 2021):
Unfortunately, way more research is needed before we can draw any definitive conclusions like this. Some studies have shown that CBD oil and estrogen may be related as CBD acts as an aromatase inhibitor. Since aromatase synthesizes estrogen, inhibiting that would actually reduce the amount of estrogen instead of increasing it. So it may seem that CBD oil does affect estrogen indirectly, but not to the result you’re looking for. This suggests that CBD oil may affect the menstrual cycle, and also that CBD oil and hemp oil may be good for hormonal imbalances, but only if you are suffering from conditions as a result of excess estrogen. However, it’s important that you understand that there is simply not enough research on this topic to have a final answer, and you should discuss something like this with your doctor beforehand.
anonymous (Thursday, March 17, 2022):
There hasn’t been enough research to say conclusively how CBD affects female hormones and the menstrual cycle. But some studies have shown that CBD may suppress the amount of estrogen produced. CBD generally promotes balance and might help with hormonal imbalance. CBD is also good for relieving menstrual cramps..